Darren Lowe played one game of junior hockey with the Kingston Canadians and spent one season in the NCAA with United States International University. He then played three years in the OUAA with the University of Toronto Varsity Blues. In 1983-84, he played with the Canadian National Team where he wore this jersey. That year, he played 67 games and scored 18 goals and added 15 assists for 33 points. Those totals include seven games in the 1984 Olympic Games in Sarajevo where he lit the lamp two times and added one assist. Lowe finished the year with the NHL's Pittsburgh Penguins where he played eight games and netted one goal with two assists. Lowe returned to the University of Toronto for the 1985-86 season.
After university, Lowe spent the 1986-87 season split with Vienna in Austria and Jokerit in Finland. He returned to North America in 1987-88 and had an excellent season with the International Hockey League's Flint Spirits where he played 82 games and scored 53 goals and had 64 assists for 117 points. Lowe spent the 1988-89 season in the American Hockey League with the Maine Mariners before returning to the Spirits for the 1989-90 season. Lowe played one final pro season in 1990-91 as a teammate of former NHLers Ron Duguay and Charlie Simmer with the IHL's San Diego Gulls. He was a prolific scorer in his three seasons in the IHL, scoring 241 points in 228 games.